T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
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On Wednesday October 19, The Medical Device Innovation Consortium (MDIC) announced its partnership with Horizon Discovery to develop and manufacture somatic reference samples (SRSs) to simplify and support the validation of NGS-based cancer diagnostics.
In this blog, we take a look at ClaretBio’s app note on using Horizon’s cfDNA reference standards in the development of their novel sample prep kit.
Learn how to examine your NGS data to investigate false positives and negatives, and potential downstream applications
Now Horizon's popular reference standards have been exome sequenced for higher confidence and expanded applications. Read on to find out how this new level of product information will support your diagnostics pipeline.
Isolation of genomic DNA from formalin fixed paraffin embedded (FFPE) tissues is a critical step for molecular diagnostic (MDx) assays. Here we investigate extraction of DNA from FFPE using five comparable methods.
We learn of several reasons why cell line derived standards have a distinct advantage on other source materials when it comes to NGS oncology assays.
Learn how reference standards play a key role in increasing and confirming the accuracy of diagnostic testing, thus bringing us closer to precision medicine and targeted therapy.
Liquid biopsy is fast becoming a realistic clinical diagnostic tool, capable of profiling the molecular makeup of a tumor that aids in choosing the right drug and in monitoring treatment response. Studies for its use in early cancer detection are already underway with promising results.
Acute Myeloid Leukaemia (AML) is a group of blood cancer malignancies that originate from the uncontrolled proliferation of blast cells in the bone marrow and circulating blood1. AML is a relatively rare disorder - representing less than 1% of total cancer cases.